Bayern Munich momentarily sit in second place, one point behind Leipzig after Julian Nagelsmann's men won eariler by 3-0 at Freiburg.
Dortmund on the other hand sit in sixth, one point behind Bayer Leverkusen - looking for a top-four finish.
Allianz Arena will play witness to an exciting clash in the Bundesliga that is bound to have huge ramifications on how the table will turn out at the end of the season.
As always, Der Klassiker is here for the spectacle. A spectacle of goals, flair, midfield tussles and attacking head-ons like no other tie in the league.
Here are the line-ups of both the teams (Kick off at 5:30pm GMT) –
Bayern Munich (4-2-3-1) –
GK – Manuel Neuer
DF – Niklas Sule, Jerome Boateng, David Alaba, Alphonso Davies
MF – L.Goretzka, Joshua Kimmich. Leroy Sane, T.Muller, Kingsley Coman
ST – Robert Lewandowski
Borussia Dortmund (4-2-3-1) –
GK – M.Hitz
DF – Thomas Muenier, Mats Hummels, D.Zagadou, N.Schulz
MF – T.Delaney, Emre Can, Marco Reus, M.Dahoud, Thorgan Hazard
ST – Erling Haaland
All eyes will be on Robert Lewandowski and Erling Haaland to knock in the goals. Jadon Sancho and Raphael Gurreiro will miss the game for Dortmund due to injury concerns, whereas Serge Gnabry finds himself on the bench
Injured/suspended for both teams: Bayern (Pavard, D.Costa, Nianzou, Tolisso, A.Nubel) & Dortmund (A.Witsel, Manuel Akanji, Sancho, Gurreiro, Reyna)