Neither Ludovic Ajorque nor Maxim Leitsch will be available for Mainz's trip to Bremen.
|Photo: Mainz 05|
Ajorque, who pulled out of Mainz's squad for Sunday's 1-1 draw with Eintracht Frankfurt after suffering an injury in the warm-up, has been ruled out with a thigh muscle strain.
Leitsch went off in the 70th minute with what has since been diagnosed as an MCL injury.
Mainz have taken just one point from their first two Bundesliga games.